Formal total synthesis of anti-helicobacter pylori agent (+)-spirolaxine methyl ether
| Title | Formal total synthesis of anti-helicobacter pylori agent (+)-spirolaxine methyl ether |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Gadakh, SK, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue | 1 |
| Pagination | 25-28 |
| Date Published | JAN |
| ISSN | 0040-4039 |
| Keywords | Brown allylation, Cu-catalyzed lactonization, Noyori's asymmetric reduction, Phthalide, Spiroketal |
| Abstract | A convergent, formal enantioselective synthesis of anti-Helicobacter pylori agent, (+)-spirolaxine methyl ether 2 has been achieved in high enantiomeric purity starting from commercially available 1,5-pentanediol. The strategy mainly comprises of the Noyori's asymmetric reduction and Brown allylation/Cu-catalyzed lactonization as the key step for the construction of key chiral intermediates, spiroketal 3 and phthalide fragment 4. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.11.047 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development