Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil
| Title | Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Mannava, MKChaitan, Bommaka, MK, Dandela, R, K. Solomon, A, Nangia, AK |
| Journal | Chemical Communications |
| Volume | 58 |
| Issue | 37 |
| Pagination | 5582-5585 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 1359-7345 |
| Abstract | Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts. |
| DOI | 10.1039/d1cc07187d |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.065 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)