First total synthesis of seimatopolide B

TitleFirst total synthesis of seimatopolide B
Publication TypeJournal Article
Year of Publication2012
AuthorsNookaraju, U, Harbindu, A, Bhise, AD, Sharma, BM, Kumar, P
JournalRSC Advances
Volume2
Issue30
Pagination11231-11234
Date PublishedOCT
Type of ArticleArticle
ISSN2046-2069
Abstract

The first enantioselective total synthesis of seimatopolide B has been achieved, using ring-closing metathesis and DCC (N,N'-dicyclohexylcarbodiimide) coupling as key steps. The stereogenic centres were generated by means of iterative hydrolytic kinetic resolution (HKR) of racemic epoxides.

DOI10.1039/c2ra21838k
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.562
Divison category: 
Organic Chemistry