First synthesis of nitrosporeusines, alkaloids with multiple biological activities
| Title | First synthesis of nitrosporeusines, alkaloids with multiple biological activities |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Philkhana, SChandra, Jachak, GR, Gunjal, VB, Dhage, NM, Bansode, AH, D. Reddy, S |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 10 |
| Pagination | 1252-1254 |
| Date Published | MAR |
| ISSN | 0040-4039 |
| Keywords | Enzymatic resolution, Influenza H1N1 virus, Maleimycin, Michael reaction, Nitrosporeusine |
| Abstract | Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product, maleimycin, in optically pure form using a gram-scale enzymatic resolution method. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.01.143 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry