FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities

TitleFeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities
Publication TypeJournal Article
Year of Publication2020
AuthorsGangadurai, C, Illa, GTeja, D. Reddy, S
JournalOrganic & Biomolecular Chemistry
Volume18
Issue41
Pagination8459-8466
Date PublishedNOV
Type of ArticleArticle
ISSN1477-0520
Abstract

There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.

DOI10.1039/d0ob01790f
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.412

Divison category: 
Organic Chemistry

Add new comment