Extending nhc-catalysis: reaction of aldehydes with unconventional reaction partners

TitleExtending nhc-catalysis: reaction of aldehydes with unconventional reaction partners
Publication TypeJournal Article
Year of Publication2011
AuthorsBiju, AT, Kuhl, N, Glorius, F
JournalAccounts of Chemical Research
Date PublishedJUL

Transition metal catalysis is a powerful means of effecting organic reactions, but it has some inherent drawbacks, such as the cost of the catalyst and the toxicity of the metals. Organocatalysis represents an attractive alternative and, in some cases, offers transformations unparalleled in metal catalysis. Unique transformations are a particular hallmark of N-heterocyclic carbene (NHC) organocatalysis, a versatile method for which a number of modes of action are known. The NHC-catalyzed umpolung (that is, the inversion of polarity) of electrophilic aldehydes, through formation of the nucleophilic Breslow intermediate, is probably the most important mode of action. In this Account, we discuss the reaction of Breslow intermediates with unconventional reaction partners.

Student Name

Council of Scientific & Industrial Research (CSIR) - India

Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)22.26
Divison category: 
Organic Chemistry