Exploration of L-proline-catalyzed -aminoxylation of aldehyde to (S)-guaifenesin-related drug molecules
| Title | Exploration of L-proline-catalyzed -aminoxylation of aldehyde to (S)-guaifenesin-related drug molecules |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Panchgalle, SP, Kunte, SS, Chavan, SP, Kalkote, UR |
| Journal | Synthetic Communications |
| Volume | 41 |
| Issue | 13 |
| Pagination | PII 937137930 |
| Date Published | MAY |
| ISSN | 0039-7911 |
| Keywords | -Aminoxylation, guaifenesin, methocarbamol, moprolol, Proline |
| Abstract | [image omitted] An efficient enantioselective synthesis of (S)-guaifenesin with 99% ee using L-proline-catalyzed -aminoxylation of aldehyde as key step is described and explored for asymmetric syntheses of (S)-moprolol and (R)-methocarbamol. |
| DOI | 10.1080/00397911.2010.493631 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.10 |
Divison category:
Organic Chemistry