Expeditious and solvent-free nickel-catalyzed C−H arylation of arenes and indoles
| Title | Expeditious and solvent-free nickel-catalyzed C−H arylation of arenes and indoles |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Jagtap, RA, Soni, V, Punji, B |
| Journal | ChemSusChem |
| Volume | 10 |
| Issue | 10 |
| Pagination | 2242-2248 |
| Date Published | APR |
| Type of Article | Article |
| Abstract | An efficient solvent-free nickel-catalyzed method for C−H bond arylation of arenes and indoles has been developed, which proceeds expeditiously through chelation assistance. The reaction is highly selective for mono-arylation and tolerates sensitive and structurally diverse functionalities, such as halides, ethers, amines, indole, pyrrole and carbazole. This reaction represents the first example of a nickel-catalyzed C−H arylation by monochelate assistance and symbolizes a rare precedent in solvent-free C−H arylation. Mechanistic investigations by various controlled reactions, kinetic studies, and deuterium labeling experiments suggest that the arylation follows a single electron transfer (SET) pathway involving the turnover-limiting C−H nickelation process. |
| DOI | 10.1002/cssc.201700321 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 7.116 |
Divison category:
Center for Material Characterization (CMC)
Add new comment