Expedient cobalt-catalyzed C–H alkynylation of (enantiopure) benzylamines
| Title | Expedient cobalt-catalyzed C–H alkynylation of (enantiopure) benzylamines |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Landge, VGokulkrish, Midya, SPrasad, Rana, J, Shinde, DR, Balaraman, E |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 20 |
| Pagination | 5252-5255 |
| Date Published | OCT |
| Keywords | Terminal Alkynes; Bond Activation; Directed Functionalization;Aminoquinoline Benzamides; Ortho-C(Sp(2))-H Bonds; Mechanistic Insights; Selective Access; Carbon-Hydrogen; Nickel; Annulation |
| Abstract | A unified strategy for cobalt-catalyzed ortho-C-H bond alkynylation of benzylamines is reported. Simple, commercially available CoBr2 was used as a cobalt source. The developed alkynylation strategy is robust and efficient and has a broad substrate scope including 1 degrees, 2 degrees, and 3 degrees benzylamines. The mechanistic study shows that C-H bond cleavage is reversible, and the kinetic study illustrates that the rate of reaction depends solely on the catalyst. |
| DOI | 10.1021/acs.orglett.6b02549 |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Catalysis and Inorganic Chemistry
Central NMR Facility