Enolate-mediated regioselective synthesis of 1,2,3-triazoles via azide-aldehydes or ketones [3+2]-cycloaddition reactions in aqueous phase
| Title | Enolate-mediated regioselective synthesis of 1,2,3-triazoles via azide-aldehydes or ketones [3+2]-cycloaddition reactions in aqueous phase |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Tripathi, A, ,, Llop, J, Chavan, SP, Joshi, SM |
| Journal | Tetrahedron Letters |
| Volume | 61 |
| Issue | 13 |
| Pagination | 151662 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Azides plus aldehydes or ketones, Click chemistry, triazoles, Water |
| Abstract | A synthetic route for the direct conversion of arylazides into the corresponding trizoles via phase transfer catalyst-assisted [3+2] cycloaddition reaction under basic conditions in aqueous medium is reported. This synthetic methodology, which offers high yields and excellent regioselectivity for varieties of triazoles at 100 degrees C for 24 h-48 h and this `greener' synthesis constitutes an alternative to the previously reported well established click reactions. Published by Elsevier Ltd. |
| DOI | 10.1016/j.tetlet.2020.151662 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.275 |
Divison category:
Chemical Engineering & Process Development
Organic Chemistry