Enceleamycins A-C, furo-naphthoquinones from amycolatopsis sp. MCC0218: isolation, structure elucidation, and antimicrobial activity
| Title | Enceleamycins A-C, furo-naphthoquinones from amycolatopsis sp. MCC0218: isolation, structure elucidation, and antimicrobial activity |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Khan, A, Said, MS, Borade, BR, Gonnade, R, Barvkar, V, Kontham, R, Dastager, SG |
| Journal | Journal of Natural Products |
| Volume | 85 |
| Issue | 5 |
| Pagination | 1267-1273 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 0163-3864 |
| Abstract | Three novel furo-naphthoquinones, enceleamycins A-C (1-3), and a new N-hydroxypyrazinone acid (4) were identified from the strain Amycolatopsis sp. MCC 0218, isolated from a soil sample collected from the Western Ghats of India. Their chemical structure and absolute and relative configurations were established by 1D and 2D NMR spectroscopy, single-crystal X-ray crystallography, and high-resolution mass spectrometry. Compounds 1 and 3 were active against methicillin-susceptible and -resistant Staphylococcus aureus with MIC values of 2-16 mu g/mL. |
| DOI | 10.1021/acs.jnatprod.1c01160 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.803 |
Divison category:
Center for Material Characterization (CMC)
National Collection of Industrial Micr-organisms (NCIM)
Organic Chemistry
Database:
Web of Science (WoS)