Enantiospecific route to (+)-(1R, 3S)-cis-chrysanthemic acid from (-)-D-pantolactone(1)

TitleEnantiospecific route to (+)-(1R, 3S)-cis-chrysanthemic acid from (-)-D-pantolactone(1)
Publication TypeJournal Article
Year of Publication2011
AuthorsHajare, AK, Datrange, LS, Murthy, YLN, Bhuniya, D, D. Reddy, S
JournalSynthesis-Stuttgart
Issue7
Pagination1067-1070
Date PublishedAPR
ISSN0039-7881
Keywordsalkenes, Metathesis, ring closure, stereoselective synthesis, Wittig reaction
Abstract

In this paper, a novel route for the synthesis of (+)-(1R,3S)-cis-chrysanthemic acid is described. The use of readily available (-)-D-pantolactone as a starting point, application of ring-closing metathesis to form the cyclopentene intermediate, and Haller-Bauer/Grob-type fragmentation to form the target compound are the highlights of the present synthesis.

DOI10.1055/s-0030-1258451
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.466
Divison category: 
Organic Chemistry