Enantioselective synthesis of (S)-alpha-arylpropionic acids via pd-catalyzed kinetic resolution of benzylic alcohols
| Title | Enantioselective synthesis of (S)-alpha-arylpropionic acids via pd-catalyzed kinetic resolution of benzylic alcohols |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Thakur, VV, Sudalai, A |
| Journal | Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry |
| Volume | 44 |
| Issue | 3 |
| Pagination | 557-562 |
| Date Published | MAR |
| ISSN | 0376-4699 |
| Abstract | A convenient synthetic route for the synthesis of three (S)-alpha-propionic acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropioilic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule. |
| Type of Journal (Indian or Foreign) | Indian |
| Impact Factor (IF) | 0.471 |
Divison category:
Chemical Engineering & Process Development