Enantioselective synthesis of (R)-(+)-alpha-lipoic acid via proline-catalyzed sequential alpha-aminoxylation and HWE olefination of aldehyde
| Title | Enantioselective synthesis of (R)-(+)-alpha-lipoic acid via proline-catalyzed sequential alpha-aminoxylation and HWE olefination of aldehyde |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Panchgalle, SP, Jogdand, GF, Chavan, SP, Kalkote, UR |
| Journal | Tetrahedron Letters |
| Volume | 51 |
| Issue | 27 |
| Pagination | 3587-3589 |
| Date Published | JUL |
| ISSN | 0040-4039 |
| Abstract | An efficient enantioselective synthesis of (R)-(+)-alpha-lipoic acid is described, in high optical purity (>97% ee), using L-proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2010.05.007 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.618 |
Divison category:
Organic Chemistry