Histrionicotoxins, the archetype of a group of spiropiperidine containing alkaloids from the brightly colored poison arrow frog Dendrobates histronicus native to the Amazon rain forests of Southern Columbia, was first isolated by Daly, Witkop and co-workers in 1971.1 They all share a common Iazaspiro[5.5]undecan-8-ol ring system with unsaturated C4 or C5 side chains at both the 2 and 7 positions. The nature and length of the side chains distinguish the different members of the histrionicotoxin family.