Enantioselective syntheses of (-)-pinellic acid, alpha- and beta-dimorphecolic acid

TitleEnantioselective syntheses of (-)-pinellic acid, alpha- and beta-dimorphecolic acid
Publication TypeJournal Article
Year of Publication2007
AuthorsBaruah, PK, Gonnade, RG, Sanjayan, GJ
JournalTetrahedron
Volume63
Issue32
Pagination7624-7633
Date PublishedAUG
Type of ArticleArticle
ISSN0040-4020
Keywordsasymmetric dihydroxylation, influenza, Sonogashira coupling
Abstract

An efficient enantioselective convergent approach for the synthesis of (-)-pinellic acid 1, alpha- and beta- dimorphecolic acid (2 and 3) from 1,9-nonane diol is described. The synthetic strategy features Sharpless asymmetric hydroxylation, Sonogashira coupling and Birch reduction. (C) 2007 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tet.2007.05.047
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)2.645
Divison category: 
Organic Chemistry