Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II
| Title | Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Kumar, P, Dubey, A, Harbindu, A |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 10 |
| Issue | 34 |
| Pagination | 6987-6994 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | An efficient high yielding improved method for the enantio- and diastereoselective cyclopropanation of chiral epoxides using triethylphosphonoacetate and base (Wadsworth-Emmons cyclopropanation) is reported. The utility of this protocol is illustrated by concise and practical synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II, a cyclopropane containing natural products. |
| DOI | 10.1039/c2ob25622c |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.568 |
Divison category:
Organic Chemistry
