Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment
| Title | Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Swaroop, PSiva, Tripathy, S, Jachak, GR, D. Reddy, S |
| Journal | Tetrahedron Letters |
| Volume | 55 |
| Issue | 34 |
| Pagination | 4777-4779 |
| Date Published | AUG |
| ISSN | 0040-4039 |
| Keywords | Cross metathesis, Enzymatic resolution, HDAC inhibitor, Microsporin, Tetrapeptide |
| Abstract | Both the isomers methyl-(2S,8R)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate and methyl-(2S,8S)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate of an unusual amino acid residue and the key fragment of microsporin B are prepared. The key steps include cross metathesis and enzymatic kinetic resolution. In addition, a linear tetrapeptide with desired components towards total synthesis is also reported. (C) 2014 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2014.06.093 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.68 |
Divison category:
Organic Chemistry