Efficient trifluoromethylation of C(sp(2))-H functionalized alpha-oxoketene dithioacetals: a route to the regioselective synthesis of functionalized trifluoromethylated pyrazoles
| Title | Efficient trifluoromethylation of C(sp(2))-H functionalized alpha-oxoketene dithioacetals: a route to the regioselective synthesis of functionalized trifluoromethylated pyrazoles |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Sharma, N, Kumari, N, Chundawat, TS, Kumar, S, Bhagat, S |
| Journal | RSC Advances |
| Volume | 7 |
| Issue | 17 |
| Pagination | 10150-10153 |
| Date Published | JAN |
| Abstract | An operationally simple approach for the regioselective construction of diversely substituted trifluoromethylated pyrazoles via nucleophilic trifluoromethylation of iodo-substituted alpha-oxoketene dithioacetals is described. X-ray crystallographic studies confirmed the trifluoromethylation as well as formation of a regioselective cyclized product. Furthermore, trifluoromethylated pyrazoles bearing thiomethyl groups may allow further functionalization and are of considerable interest in medicinal chemistry. |
| DOI | 10.1039/c7ra01130j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Physical and Materials Chemistry