Efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction
Title | Efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Bhattacharya, AK, Rana, KC, Raut, DS, Mhaindarkar, VP, Khan, MIslam |
Journal | Organic & Biomolecular Chemistry |
Volume | 9 |
Issue | 15 |
Pagination | 5407-5413 |
Date Published | OCT |
ISSN | 1477-0520 |
Abstract | A novel one-pot route for the synthesis of benzodiazepinyl phosphonates (BDPs) has been achieved. FeCl3 efficiently catalyzed four-component condensation of diamines, acetone and phosphites in the presence of molecular sieves to furnish BDPs as novel chemical entities with good yield. The synthesized BDPs have shown significant protease inhibition activity against clostripain, a disease model for gas gangrene, suggesting that these novel chemical entities could be further explored as cysteine protease inhibitors. |
DOI | 10.1039/c0ob01102a |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 3.85 |
Divison category:
Biochemical Sciences
Organic Chemistry