Efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction

TitleEfficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction
Publication TypeJournal Article
Year of Publication2011
AuthorsBhattacharya, AK, Rana, KC, Raut, DS, Mhaindarkar, VP, Khan, MIslam
JournalOrganic & Biomolecular Chemistry
Volume9
Issue15
Pagination5407-5413
Date PublishedOCT
ISSN1477-0520
Abstract

A novel one-pot route for the synthesis of benzodiazepinyl phosphonates (BDPs) has been achieved. FeCl3 efficiently catalyzed four-component condensation of diamines, acetone and phosphites in the presence of molecular sieves to furnish BDPs as novel chemical entities with good yield. The synthesized BDPs have shown significant protease inhibition activity against clostripain, a disease model for gas gangrene, suggesting that these novel chemical entities could be further explored as cysteine protease inhibitors.

DOI10.1039/c0ob01102a
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)3.85
Divison category: 
Biochemical Sciences
Organic Chemistry