Efficient synthesis of 2,3-aziridino-gamma-lactones from azetidin-2-ones
| Title | Efficient synthesis of 2,3-aziridino-gamma-lactones from azetidin-2-ones |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kale, AS, Deshmukh, ARAS |
| Journal | Synlett |
| Issue | 15 |
| Pagination | 2370-2372 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0936-5214 |
| Keywords | azetidin-2-ones, aziridines, glutamic acid, lactones |
| Abstract | An efficient synthesis of enantiopure 2,3-aziridino-gamma-lactones from azetidin-2-ones is described. Acid-catalyzed tandem intramolecular azetidinone ring opening followed by aziridine ring formation via elimination of a mesylate group is the key step in this synthesis. 2,3-Aziridino-gamma-lactones are important precursors for biologically important glutamic acid derivatives. |
| DOI | 10.1055/s-2005-875563 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.323 |
Divison category:
Organic Chemistry