Efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework
| Title | Efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Chavan, SS, Supekar, MV, Burate, PA, Rupanwar, BD, Shelke, AM, Suryavanshi, G |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 15 |
| Issue | 11 |
| Pagination | 2385-2391 |
| Date Published | MAR |
| Abstract | A novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C-N cyclization reaction. |
| DOI | 10.1039/c7ob00294g |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Chemical Engineering & Process Development
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