Efficient palladium catalyzed Mizoroki-Heck cross-coupling in water
| Title | Efficient palladium catalyzed Mizoroki-Heck cross-coupling in water |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Jadhav, SN, Rode, CV |
| Journal | Green Chemistry |
| Volume | 19 |
| Issue | 24 |
| Pagination | 5958-5970 |
| Date Published | DEC |
| Type of Article | Article |
| Abstract | The homogeneous Pd-catalysed Mizoroki-Heck coupling reaction was successfully performed in water in the absence of any additives under aerobic conditions. The various key reaction parameters that affect the yield of the desired cross-coupling product were optimized. The Pd(PPh3)(4)/Et3N/H2O/98 degrees C catalyst system was found to be highly active (TOF = 12 to 14 h(-1)) towards achieving excellent yield of the Mizoroki-Heck coupling products for a wide range of electron-withdrawing as well as electron-donating aryl bromides and chlorides in the shortest reaction time. Pd(PPh3) 4 catalyst deactivation during the Mizoroki-Heck coupling reaction was investigated and to evolve a strategy for achieving ten times Pd-metal recyclability without appreciable loss of its activity. Thus, the proposed mechanism provides access to a variety of olefins in aqueous medium, making this protocol eco-friendly. |
| DOI | 10.1039/c7gc02869e |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 9.125 |
Divison category:
Chemical Engineering & Process Development