Efficient organocatalytic route for asymmetric total synthesis of stagonolide F
| Title | Efficient organocatalytic route for asymmetric total synthesis of stagonolide F |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Shelke, AM, Suryavanshi, G |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 45 |
| Pagination | 6207-6209 |
| Date Published | NOV |
| ISSN | 0040-4039 |
| Keywords | alpha-Aminooxylation, Jorgensens's asymmetric epoxidation, Macrolide, Ring-closing metathesis, Total synthesis |
| Abstract | A stereoselective total synthesis of Stagonolide F (98% ee) is described employing asymmetric alpha-aminooxylation, Jorgensen's asymmetric epoxidation, Brown asymmetric allylation, Steglich esterification and ring closing metathesis as key steps. The use of organocatalytic alpha-aminooxylation and Jorgensen's asymmetric epoxidation of aldehydes for the introduction of chirality makes this approach more attractive. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.09.082 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development