Efficient one pot regioselective synthesis of a 3,3 `-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones
| Title | Efficient one pot regioselective synthesis of a 3,3 `-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Shelke, AM, Suryavanshi, G |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 13 |
| Issue | 32 |
| Pagination | 8669-8675 |
| Date Published | JUL |
| ISSN | 1477-0520 |
| Abstract | A one pot, highly regioselective synthesis of racemic 3,3'-spiro-phosphonylpyrazole-oxindole by 1,3-dipolar cycloaddition of an in situ generated anion of dialkyl 1-diazomethylphosphonate from the Bestmann-Ohira reagent (BOR) & methyleneindolinones has been developed. The synthesis affords the highly functionalized pyrazole scaffolds in good yields with excellent regioselectivity under mild reaction conditions within a short reaction time. |
| DOI | 10.1039/c5ob01020a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Chemical Engineering & Process Development