Efficient convergent access to spiroketal segment of (+)-spiroxaline methyl ether
| Title | Efficient convergent access to spiroketal segment of (+)-spiroxaline methyl ether |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Singh, M, Argade, NP |
| Journal | Synthesis-Stuttgart |
| Volume | 2 |
| Issue | 1 |
| Pagination | 1137-1141 |
| Date Published | APR |
| ISSN | 0039-7881 |
| Keywords | (+)-spiroketal segment synthesis, (R)-gamma-valerolactone, (R)-oxirane, alkyne, nucleophilic reactions |
| Abstract | Starting from trimethylsilylacetylene, a facile synthesis of optically pure spiroketal unit of (+)-spiroxaline methyl ether has been described. The synthesis entails stepwise alkylation and acylation of an alkyne with two different readily available chiral building blocks followed by the reductive in situ regio- and stereoselective spiroketalization pathway. |
| DOI | 10.1055/s-0030-1258456 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.466 |
Divison category:
Organic Chemistry