Efficient access to enantiopure 1,3-disubstituted isoindolines from selective catalytic fragmentation of an original desymmetrized rigid overbred template
| Title | Efficient access to enantiopure 1,3-disubstituted isoindolines from selective catalytic fragmentation of an original desymmetrized rigid overbred template |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Pandey, G, Varkhedkar, R, Tiwari, D |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 13 |
| Issue | 15 |
| Pagination | 4438-4448 |
| Date Published | MAR |
| ISSN | 1477-0520 |
| Abstract | An efficient and scalable synthesis of various enantiopure 1,3-disubstituted isoindolines is reported. The base catalyzed nucleophilic fragmentation of a rigid overbred template is established with various substrates to afford the corresponding 1,3-disubstituted isoindoline ester, amide, thioate, 1,3-amino alcohol and isoindolylcarboxylic acid. The crucial rigid overbred template is synthesized in an optically pure form in multigram scale by asymmetric desymmetrization of the corresponding meso compound. |
| DOI | 10.1039/c5ob00229j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Organic Chemistry