Diversity-oriented synthesis of spiroannulated benzofuran-3-one scaffold of leptosphaerin C and congeners via aryne insertion
| Title | Diversity-oriented synthesis of spiroannulated benzofuran-3-one scaffold of leptosphaerin C and congeners via aryne insertion |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Dhokale, RA, Mhaske, SB |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Issue | 9 |
| Pagination | 4875-4882 |
| Date Published | MAY |
| Type of Article | Article |
| Abstract | A concise synthesis of functionalized cyclohexenone-fused spirobenzofuran-3-ones under mild reaction conditions was developed. The reaction proceeds via insertion of aryne into the C-O bond followed by a regioselective intramolecular conjugate addition. The use of silyl-protected acid was crucial for the transformation. This protocol was successfully applied for the synthesis of leptosphaerin C core and its novel analogues. |
| DOI | 10.1021/acs.joc.7b00606 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Organic Chemistry
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