Diversification of quinazolinones by Pd-catalyzed C(sp(3))-acetoxylation
| Title | Diversification of quinazolinones by Pd-catalyzed C(sp(3))-acetoxylation |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Garad, DN, Mhaske, SB |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Issue | 19 |
| Pagination | 10470-10478 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | The quinazolinone ring has been exploited as a directing group for C(sp(3))-H functionalization for the first time. The proximal C-gamma(sp3)-H bonds have been oxidized by palladium-catalyzed acetoxylation reaction. Various functional groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives. The use of base was found to be crucial for the mono selective acetoxylations. |
| DOI | 10.1021/acs.joc.7b01934 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.849 |
Divison category:
Organic Chemistry
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