Divergent synthesis of 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) using DMSO as a single carbon synthon
| Title | Divergent synthesis of 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) using DMSO as a single carbon synthon |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Sikdar, P, Das, S, Saini, S, Sawant, SD, Bagdi, AKumar |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 23 |
| Issue | 33 |
| Pagination | 7566-7570 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | A divergent approach has been explored for synthesizing 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) using DMSO as a C1 synthon. A library of 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) has been synthesized using CuOAc and AcOH, respectively. The reaction progressed through a radical pathway. The usefulness of 3-formylpyrazolo[1,5-a]pyrimidines in synthesizing a zaleplon derivative has been demonstrated. |
| DOI | 10.1039/d5ob01042j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.8 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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