Direct deoxygenation of α-hydroxy and α,β-dihydroxy ketones using a silyl lithium reagent
| Title | Direct deoxygenation of α-hydroxy and α,β-dihydroxy ketones using a silyl lithium reagent |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Zade, VM, Gangnale, LD, Athawale, PR, D. Reddy, S |
| Journal | Journal of Organic Chemistry |
| Volume | 88 |
| Issue | 19 |
| Pagination | 14227-14235 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | A reliable method for the one-step direct deoxygenation of alpha-hydroxy ketones has been developed using a silyl lithium reagent and acetic anhydride. The method is metal-catalyst-free and does not require prefunctionalization of the hydroxy group prior to its removal. Deoxygenation of different primary, secondary, and tertiary alcohols was carried out with up to 98% isolated yield. Additionally, double deoxygenation was achieved when the present method was applied to alpha,beta-dihydroxy ketones to access the corresponding enones in a single step. |
| DOI | 10.1021/acs.joc.3c01613 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.6 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)