Direct allylation of in situ generated aldehyde acyl anions by synergistic NHC and palladium catalysis

TitleDirect allylation of in situ generated aldehyde acyl anions by synergistic NHC and palladium catalysis
Publication TypeJournal Article
Year of Publication2014
AuthorsAhire, MM, Mhaske, SB
JournalAngewandte Chemie-International Edition
Volume53
Issue27
Pagination7038-7042
Date PublishedJUL
Type of ArticleArticle
ISSN1433-7851
Keywordsaldehyde umpolung, C allylation, N-heterocyclic carbenes, Palladium, synergistic catalysis
Abstract

The direct regioselective allylation of in situ generated aldehyde acyl anions has been achieved by synergistic NHC and Pd catalysis. It provides an efficient access to valuable beta,gamma-unsaturated ketones under mild reaction conditions starting from easily accessible allylic carbonates and aldehydes without any preactivation. The synergistic catalysis method demonstrated herein adds a new dimension to the area of metal-mediated C allylation.

DOI10.1002/anie.201400623
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

11.709

Divison category: 
Organic Chemistry