Dimensionality reduction in computational demarcation of protein tertiary structures

TitleDimensionality reduction in computational demarcation of protein tertiary structures
Publication TypeJournal Article
Year of Publication2012
AuthorsJoshi, RR, Panigrahi, PR, Patil, RN
JournalJournal of Molecular Modeling
Volume18
Issue6
Pagination2741-2754
Date PublishedJUN
ISSN1610-2940
KeywordsLogistic regression, Principal component analysis, Protein structural classes, Quantitative features of tertiary folds, SCOP database
Abstract

Predictive classification of major structural families and fold types of proteins is investigated deploying logistic regression. Only five to seven dimensional quantitative feature vector representations of tertiary structures are found adequate. Results for benchmark sample of non-homologous proteins from SCOP database are presented. Importance of this work as compared to homology modeling and best-known quantitative approaches is highlighted.

DOI10.1007/s00894-011-1223-0
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)1.984
Divison category: 
Biochemical Sciences