Dimedone-based rigid organic scaffold for organizing symmetrical helical peptide chains.

TitleDimedone-based rigid organic scaffold for organizing symmetrical helical peptide chains.
Publication TypeJournal Article
Year of Publication2019
AuthorsMadica, K, Lakshmi, JK, Madhu, S, Nadimpally, KChaitanya, Gonnade, R, Jagadeesh, B, Sanjayan, GJ
JournalChemistrySelect
Volume4
Issue39
Pagination11518-11522
Date PublishedOCT
Type of ArticleArticle
ISSN2365-6549
Keywordsdimedone, Helical, hydrogen bonding, Peptides, template
Abstract

We describe herein design, synthesis and conformational investigations of polypeptides attached on a rigid dimedone template. Two identical peptide chains are attached on a single carbon containing dimedone as a scaffold. Dimedone assists in controlling the secondary interactions through strong intramolecular helical C-12 and C-15 membered bifurcated hydrogen bonding on both the peptide chains along with propagating the helical architecture of the peptide chains attached. There exists a C-6 hydrogen bonding for the single stranded peptides attached to dimedone. Extensive structural investigations involving single crystal X-ray diffraction, solution-state NMR and CD studies of oligopeptides have been undertaken.

DOI10.1002/slct.201903087
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.716

Divison category: 
Center for Material Characterization (CMC)
Organic Chemistry

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