Diethylamine: a smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature
| Title | Diethylamine: a smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Kulkarni, MA, Pandit, KS, Desai, UV, Lad, UP, Wadgaonkar, PP |
| Journal | Comptes Rendus Chimie |
| Volume | 16 |
| Issue | 8 |
| Pagination | 689-695 |
| Date Published | AUG |
| ISSN | 1631-0748 |
| Keywords | 2-amino-4H-chromenes, Active methylene compounds (C-H acids), diethylamine, multicomponent reactions, organocatalyst |
| Abstract | Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz, ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a ``near-ideal synthesis''. (c) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved. |
| DOI | 10.1016/j.crci.2013.02.016 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.49 |
Divison category:
Polymer Science & Engineering