Diethylamine Dess-Martin periodinane: an efficient catalyst-oxidant combination in a sequential, one-pot synthesis of difficult to access 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature
| Title | Diethylamine Dess-Martin periodinane: an efficient catalyst-oxidant combination in a sequential, one-pot synthesis of difficult to access 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kupwade, RV, Khot, S, Kulkarni, MA, Desai, UV, Wadgaonkar, PP |
| Journal | RSC Advances |
| Volume | 7 |
| Issue | 62 |
| Pagination | 38877-38883 |
| Date Published | AUG |
| Type of Article | Article |
| Abstract | Herein, diethylamine Dess–Martin periodinane has been demonstrated for the first time as an efficient catalyst–oxidant combination in a sequential, one-pot synthesis of medicinally privileged but difficult to access 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines via a pseudo-four component reaction between 2,6-disubstituted benzaldehydes, malononitrile, and thiols. Ambient reaction conditions, excellent yields, and total avoidance of conventional isolation as well as purification are the noteworthy merits of this developed protocol. |
| DOI | 10.1039/C7RA07738F |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Polymer Science & Engineering