Determination of the absolute configuration of gliomasolide D through total syntheses of the C-17 epimers
| Title | Determination of the absolute configuration of gliomasolide D through total syntheses of the C-17 epimers |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Seetharamsingh, B, Ganesh, R, D. Reddy, S |
| Journal | Journal of Natural Products |
| Volume | 80 |
| Issue | 2 |
| Pagination | 560-564 |
| Date Published | FEB |
| Abstract | The absolute configuration at C-17, the carbon bearing the distal hydroxy group of the 14-membered natural product gliomasolide D, was assigned as R by comparison of C-13 NMR shifts and specific rotation values of the epimers at C-17. The first total synthesis of gliomasolide D along with its C-17 epimer, regioselective macrocyclization (18 membered vs 14 membered), and regioselective Wacker oxidation are highlights of the present work. |
| DOI | 10.1021/acs.jnatprod.6b00926 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.662 |
Divison category:
Organic Chemistry