Design, synthesis and cytotoxicity of novel N-benzylpiperidin-4-one oximes on human cervical cancer cells
| Title | Design, synthesis and cytotoxicity of novel N-benzylpiperidin-4-one oximes on human cervical cancer cells |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Dindulkar, SD, Bhatnagar, I, Gawade, RL, Puranik, VG, Kim, S-K, Anh, DHyun, Parthiban, P, Jeong, YTae |
| Journal | Journal of Chemical Sciences |
| Volume | 126 |
| Issue | 3 |
| Pagination | 861-873 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 0974-3626 |
| Keywords | Cytotoxicity, HeLa cells, N-benzylpiperidin-4-one oximes, single-crystal XRD |
| Abstract | A series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Additionally, single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as E-isomer as witnessed by their NMR and XRD data. Among the synthesized target compounds that evaluated for their in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, five compounds were potent with IC50 < 17 mu M. 1-Benzyl-2,6-bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime 3c with an IC50 of 13.88 mu M was found to be the best active compound as depicted by the microscopic analysis. |
| DOI | 10.1007/s12039-014-0622-z |
| Type of Journal (Indian or Foreign) | Indian |
| Impact Factor (IF) | 1.085 |
Divison category:
Center for Material Characterization (CMC)