Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability
| Title | Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Suresh, K, Nangia, A |
| Journal | Crystengcomm |
| Volume | 20 |
| Issue | 24 |
| Pagination | 3277-3296 |
| Date Published | JUN |
| Abstract | Curcumin (CUR) is the prime curcuminoid in the Indian dietary spice turmeric, Curcuma longa, a plant of the Zingiberaceae family. CUR has promising and diverse therapeutic benefits, such as antioxidant, anti-inflammatory, antitumor, anti-hyperglycemic, antimalarial, antibacterial, and antiviral activity, including anti-Alzheimer's disease. However, CUR is yet to reach the status of a therapeutic drug candidate mainly because a standard solid dosage of curcumin suffers from poor oral bioavailability (0.05 g mL(-1), less than 1%). The reasons behind its low bioavailability include poor solubility ( |
| DOI | 10.1039/c8ce00469b |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.474 |
Divison category:
Physical and Materials Chemistry