Cucurbit[7]uril induced formation of fret-enabled unilamellar lipid vesicles

TitleCucurbit[7]uril induced formation of fret-enabled unilamellar lipid vesicles
Publication TypeJournal Article
Year of Publication2017
AuthorsKushwaha, S, Maity, A, Gangopadhyay, M, Ravindranathan, S, Rajamohanan, PR, Das, A
JournalLangmuir
Volume33
Issue41
Pagination10989-10999
Date PublishedOCT
Type of ArticleArticle
AbstractA unique fluorescence resonance energy transfer (FRET) process is found to be operational in a unilamellar lipid self-assembly in the aqueous phase. A newly synthesized naphthyl based long chain lipid derivative [N-(naphthalene-1-ylmethyl)tetradecane-1-ammonium chloride, 14NA(+)] forms various self-assembled architectures in the aqueous phase. Controlled changes in lipid concentration lead to a transition of the self-assemblies from micelles to vesicles to rods. In the presence of cucurbit[7]uril (CB7), 14NA(+) forms a host-guest [2]pseudorotaxane complex (CB7(sic)14NA(+)) and secondary interactions lead to the formation of a lipid bilayer with hydrophobic pockets situated in between the layers. The change in the structure of 14NA(+) assemblies, interaction with CB7 and formation of supramolecular assemblies of CB7(sic)14NA(+) were examined using light scattering, spectroscopic, and microscopic techniques. Entrapment of a luminescent dye, anthracene within the hydrophobic bilayer of the supramolecular assembly CB7(sic)14NA(+) favors a modified luminescent response due to an efficient FRET process. Further, the FRET process could be controlled by thermal and chemical stimuli that induce transformation of unilamellar vesicles.
DOI10.1021/acs.langmuir.7b02777
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)3.833
Divison category: 
Central NMR Facility
Organic Chemistry

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