Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability
| Title | Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Bose, T, Kumar, VA |
| Journal | Tetrahedron |
| Volume | 73 |
| Issue | 12 |
| Pagination | 1534-1540 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | ESI-MS study, G-quadruplex, Peptide nucleic acid, topology |
| Abstract | An uncharged PNA 15mer sequence formed unimolecular antiparallel G-quadruplex similar to that observed for DNA-TBA. Replacement of `tt' loop regions by peptides which induce helices or turns were found to have unpresidented effect on the quadruplex topology and stability. This study opens up a completely new strategy of utilizing G-quadruplex formation to display the array of functional groups in the three dimensional space thus creating a possibility of getting closer to the dream of designed peptides with three dimensional structures as observed in catalytic protein folds. (C) 2017 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2017.01.055 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.377 |
Divison category:
Organic Chemistry