Critical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability

TitleCritical role of select peptides in the loop region of G-rich PNA in the preferred G-quadruplex topology and stability
Publication TypeJournal Article
Year of Publication2017
AuthorsBose, T, Kumar, VA
JournalTetrahedron
Volume73
Issue12
Pagination1534-1540
Date PublishedMAR
Type of ArticleArticle
ISSN0040-4020
KeywordsESI-MS study, G-quadruplex, Peptide nucleic acid, topology
Abstract

An uncharged PNA 15mer sequence formed unimolecular antiparallel G-quadruplex similar to that observed for DNA-TBA. Replacement of `tt' loop regions by peptides which induce helices or turns were found to have unpresidented effect on the quadruplex topology and stability. This study opens up a completely new strategy of utilizing G-quadruplex formation to display the array of functional groups in the three dimensional space thus creating a possibility of getting closer to the dream of designed peptides with three dimensional structures as observed in catalytic protein folds. (C) 2017 Elsevier Ltd. All rights reserved.
DOI10.1016/j.tet.2017.01.055
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.377
Divison category: 
Organic Chemistry

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