Convenient synthesis of the enantiomerically pure beta-blocker (S)-betaxolol using hydrolytic kinetic resolution
| Title | Convenient synthesis of the enantiomerically pure beta-blocker (S)-betaxolol using hydrolytic kinetic resolution |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Joshi, RA, Garud, DR, Muthukrishnan, M, Joshi, RR, Gurjar, MK |
| Journal | Tetrahedron-Asymmetry |
| Volume | 16 |
| Issue | 23 |
| Pagination | 3802-3806 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0957-4166 |
| Abstract | Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up. (c) 2005 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2005.10.028 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.108 |
Divison category:
Organic Chemistry