Convenient access to 1, 3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation
| Title | Convenient access to 1, 3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | N. Rai, S, Kalluraya, B, Lingappa, B, Shenoy, S, Puranik, VG |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 43 |
| Issue | 8 |
| Pagination | 1715-1720 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 0223-5234 |
| Keywords | 1, 3-dipolar cycloaddition, 5-nitrothiophene, acetylenic ketone, Antibacterial, antifungal, Pyrazole, sydnone |
| Abstract | Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn- 1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article. (c) 2007 Elsevier Masson SAS. All fights reserved. |
| DOI | 10.1016/j.ejmech.2007.08.002 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.902 |
Divison category:
Center for Material Characterization (CMC)
Physical and Materials Chemistry