Concise/catalytic approach for the construction of the C14-C28 fragment of eribulin
| Title | Concise/catalytic approach for the construction of the C14-C28 fragment of eribulin |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Senapati, S, , |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 19 |
| Issue | 20 |
| Pagination | 4542-4550 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | A simple approach for the synthesis of the C14-C28 fragment of eribulin has been developed by employing a one-pot gold-catalyzed alkynol cyclization/Kishi reduction to construct the 1,5-cis-tetrahydropyran unit and a cross-metathesis/Sharpless asymmetric dihydroxylation-cycloetherification to install the 1,4-trans-tetrahydrofuran ring. Use of easily accessible building blocks, ease of operation and catalytic transformations as key reactions for the construction of THF/THP units highlight the current approach. |
| DOI | 10.1039/d1ob00661d, Early Access Date = APR 2021 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.876 |
Divison category:
Organic Chemistry