Concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

TitleConcise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM
Publication TypeJournal Article
Year of Publication2014
AuthorsChavan, SP, Chavan, PN, Khairnar, LB
JournalRSC Advances
Volume4
Issue22
Pagination11417-11419
Date PublishedFEB
Type of ArticleArticle
ISSN 2046-2069
AbstractA synthesis of oseltamivir (Tamiflu) was achieved starting from D-mannitol. A unique feature of the synthetic route is that an acyclic precursor was constructed, which was then cyclized in an intramolecular aldol reaction to form the Tamiflu skeleton. Throughout the synthesis, well-established, highly efficient reactions were employed, and no protection/deprotection sequence was needed.
DOI10.1039/C3RA47210H
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)3.06
Divison category: 
Organic Chemistry

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