Concise synthesis of protected (2S,4R)-4-hydroxyornithine
| Title | Concise synthesis of protected (2S,4R)-4-hydroxyornithine |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Pandey, SKumar, Pandey, M, Kumar, P |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue | 20 |
| Pagination | 3297-3299 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Epoxide, Grignard reaction, hydroxyornithine, Jacobsen's HKR, Natural product |
| Abstract | A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio- and diastereoselectivity using Jacobsen's hydrolytic kinetic resolution (HKR) and regioselective opening of an epoxide as key steps. (c) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2008.03.076 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry