Concise enantioselective synthesis of (+)-sertraline and (-)-CP-52002 using proline catalysis
| Title | Concise enantioselective synthesis of (+)-sertraline and (-)-CP-52002 using proline catalysis |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kalshetti, RG, Venkataramasubramanian, V, Kamble, SP, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue | 9 |
| Pagination | 1053-1055 |
| Date Published | MAR |
| ISSN | 0040-4039 |
| Keywords | Indatraline, Mannich reaction, Proline catalysis, Sertraline, Tametraline |
| Abstract | A short enantioselective synthesis of (+)-sertraline and its C-4 epimer (-)-CP-52002 with an overall yield of 30%, respectively, as its hydrochloride has been described. The key steps are the proline catalyzed Mannich reaction of acetaldehyde and acid catalyzed intramolecular Friedel-Crafts' alkylation reaction of olefin proceeding with high optical purities. (C) 2016 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2016.01.085 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development