Concise approach for the synthesis of the tetracyclic framework of Lycibarbarines A and B
| Title | Concise approach for the synthesis of the tetracyclic framework of Lycibarbarines A and B |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Shet, MN, Nechooli, HK, Ramana, CV |
| Journal | Tetrahedron Letters |
| Volume | 121 |
| Pagination | 154493 |
| Date Published | MAY 17 |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Chiral pool approach, D -Glyceraldehyde, Tetracyclic spiroketal, Total synthesis |
| Abstract | A simple approach for the construction of the tetracyclic spiroketal skeleton of Lycibarbarine A and B has been described. Employing a solvent free condition for epoxide opening with tetrahydroquinoline as a key reaction to couple both the fragments, an oxidation followed by TBAF-mediated silyl deprotection spiroketalization establishes the complete tetracyclic core present in these natural products. (c) 2023 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2023.154493 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.8 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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