Concise approach for central core of trigolutes: total synthesis of trigolute B and 3-epi-trigolute B and analogues

TitleConcise approach for central core of trigolutes: total synthesis of trigolute B and 3-epi-trigolute B and analogues
Publication TypeJournal Article
Year of Publication2017
AuthorsB. Reddy, N, Ramana, CV
JournalTetrahedron
Volume73
Issue7
Pagination888 - 899
Date PublishedFEB
Abstract

A concise approach comprising a combination of the Pd- or Ir-catalyzed Tsuji-Trost allylation and olefin dihydrox-ylation/acid catalyzed lactonization has been developed to construct the central spirolactone core of trigolutes with the requisite functional groups. A large number of analogues of trigolute B have been synthesized. Furthermore, the synthesis of both (±)-trigolute B and (±)-3-epi-trigolute B has been accomplished in 4–5 steps from easily accessible building blocks.

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.645

Divison category: 
Organic Chemistry