Co(III)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: its application in the synthesis of ICI-118,551, an anti-hypertensive agent
| Title | Co(III)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: its application in the synthesis of ICI-118,551, an anti-hypertensive agent |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Karabal, PU, Kamble, DA, Sudalai, A |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 12 |
| Issue | 15 |
| Pagination | 2349-2355 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | The salen Co(III)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti-or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a beta-blocker, in a highly optically pure form (99% ee). |
| DOI | 10.1039/c3ob42501k |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Chemical Engineering & Process Development